4,4-二苯基-3-丁烯酸合成路线 （共 33 条）
反应条件
1: 9.2 g / H2 / palladium on charcoal / methanol / 3 h / 710 Torr 2: 7.6 g / polyphosphoric acid / 1 h / 90 °C View Scheme
参考文献
Kopecky, Karl R.; Hall, Michael C.
Canadian Journal of Chemistry, 1981 , vol. 59, p. 3095 - 3104
反应条件
piperidine
T=85°C; Knoevenagel condensation; 3 h;
参考文献
Hudgens, Debjani P.; Taylor, Catherine; Batts, Timothy W.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 24 p. 8366 - 8378
反应条件
1: With potassium hydride in tetrahydrofuran
T=0°C; 0.25 h;
2: With tert.-butyl lithium in tetrahydrofuran
T=-78 - 0°C;
3: With sodium hydroxide
T=0 - 20°C;
参考文献
Satoh, Tsuyoshi; Nakamura, Akira; Iriuchijima, Atsuko; Hayashi, Yasumasa; Kubota, Ko-Ichi
Tetrahedron, 2001 , vol. 57, # 48 p. 9689 - 9696
反应条件
hydrogenchloride in ethanol
24 h;
参考文献
Katritzky, Alan R.; Feng, Daming; Lang, Hengyuan
Journal of Organic Chemistry, 1997 , vol. 62, # 12 p. 4131 - 4136
反应条件
hydrogen bromide; acetic acid
参考文献
Jeffery; Fry
Journal of Organic Chemistry, 1957 , vol. 22, p. 735,737
Show Details
Johnson; Petersen; Schneider
Journal of the American Chemical Society, 1947 , vol. 69, p. 74,77
反应条件
hydrogen bromide; acetic acid
参考文献
Jeffery; Fry
Journal of Organic Chemistry, 1957 , vol. 22, p. 735,737
Show Details
Johnson; Petersen; Schneider
Journal of the American Chemical Society, 1947 , vol. 69, p. 74,77
反应条件
hydrogen bromide; acetic acid
参考文献
Howden,M.E.H. et al.
Journal of the American Chemical Society, 1966 , vol. 88, p. 1732 - 1742
反应条件
hydrogenchloride in ethanol
21 h; Heating;
参考文献
Kurosawa, Kazu; Tsujita, Tsuyoshi
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 8 p. 2391 - 2394
反应条件
aluminium trichloride in nitrobenzene
6 h; Ambient temperature;
参考文献
Joshi, U. R.; Khadilkar, B. M.; Samant, S. D.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, p. 75 - 76
反应条件
1: 85 percent / benzoic acid / benzene / 12 h / Heating
2: Na, ethanol / 18 h / Heating
View Scheme
参考文献
Gualtieri; Teodori; Bellucci; Pesce; Piacenza
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1621 - 1628
