3-甲基-2-苯基喹啉-4-羧酸甲酯合成路线 （共 17 条）
反应条件
N-bromosuccinmide; acetic acid; dibenzoyl peroxide in tetrachloromethane; benzene 3.5 h; UV-irradiationInert atmosphereReflux;
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
Location in patent: Page/Page column 50-51 ;
反应条件
N-bromosuccinmide in acetonitrile
参考文献
Farina, Carlo; Giardina, Giuseppe; Grugni, Mario; Gerard, Guy Marguerite Marie
Patent: US2004/77658 A1, 2004 ;
反应条件
in methanol; hexanes; dichloromethane
T=0 - 20°C; 1 h;
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
Location in patent: Page/Page column 50 ;
反应条件
in methanol; dichloromethane; N,N-dimethyl-formamide
参考文献
SmithKline Beecham S.p.A.; SmithKline Beecham Laboratoires Phamaceutiques
Patent: US6613770 B1, 2003 ;
US 6613770 B1
反应条件
sodium methylate in methanol
2 h; Heating;
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
反应条件
1.1: oxalyl chloride / CH2Cl2 / 0.5 h / 20 °C
1.2: DMF / CH2Cl2 / 0.5 h
2.1: CH2Cl2 / 18 h
View Scheme
参考文献
Blaney; Raveglia; Artico; Cavagnera; Dartois; Farina; Grugni; Gagliardi; Luttmann; Martinelli; Nadler; Parini; Petrillo; Sarau; Scheideler; Hay; Giardina
Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1675 - 1689
反应条件
1: NaOMe / methanol / 2 h / Heating
2: 35percent H2O2 / acetic acid / 7 h / 90 - 95 °C
3: CDCl3 / Irradiation
4: 11.3 percent / acetone; H2O / Ambient temperature
View Scheme
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
反应条件
1: 33percent aq. KOH / ethanol / Heating
2: NaOMe / methanol / 2 h / Heating
3: 35percent H2O2 / acetic acid / 7 h / 90 - 95 °C
4: CDCl3 / Irradiation
5: 11.3 percent / acetone; H2O / Ambient temperature
View Scheme
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
反应条件
1: 35percent H2O2 / acetic acid / 7 h / 90 - 95 °C
2: CDCl3 / Irradiation
3: 11.3 percent / acetone; H2O / Ambient temperature
View Scheme
参考文献
Kaneko; Fujii; Kawai; et al.
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 4 p. 1157 - 1171
反应条件
1.1: potassium hydroxide / ethanol; water / 0.17 h
1.2: 18 h / Reflux
2.1: dichloromethane; hexanes; methanol / 1 h / 0 - 20 °C
View Scheme
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M; HILFKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119704 A1, 2011 ;
