2,4-二氯-5,7-二氢噻吩并[3,4-d]嘧啶合成路线 （共 4 条）
反应条件
dichlorophenyl phosphine oxide
T=135 - 165°C;
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
Location in patent: Page/Page column 42; 56 ;
反应条件
1: lithium methanolate / toluene / 18.5 h / 70 - 110 °C
2: sodium carbonate / water / 20 °C / |Darkness
3: water; hydrogenchloride; acetic acid / |Reflux
4: dichlorophenyl phosphine oxide / 135 - 165 °C
View Scheme
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
反应条件
1: sodium carbonate / water / 20 °C / |Darkness
2: water; hydrogenchloride; acetic acid / |Reflux
3: dichlorophenyl phosphine oxide / 135 - 165 °C
View Scheme
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
反应条件
1: water; hydrogenchloride; acetic acid / |Reflux
2: dichlorophenyl phosphine oxide / 135 - 165 °C
View Scheme
参考文献
CELLZOME LIMITED; LYNCH, Rosemary; CANSFIELD, Andrew David; HARDY, Daniel Paul; FEUTRILL, John Thomas; ADREGO, Rita; ELLARD, Katie; LADDUWAHETTY, Tammy
Patent: WO2013/50508 A1, 2013 ;
