BOC-4-去氢-L-脯氨酸合成路线 （共 35 条）
反应条件
1: in toluene T=75°C; 4 h; 2: With potassium hydroxide in water; toluene Product distribution / selectivity;
参考文献
WO2006/80401 A1, ;
Page/Page column 36-38 ;
反应条件
lithium hydroxide in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Shangguan, Ning; Joullie, Madeleine
Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6748 - 6750
反应条件
1: With sodium hydroxide; water T=40°C; 2 h; 2: With hydrogenchloride in water T=5°C; pH=5; 3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: WO2006/80401 A1, 2006 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: With sodium hydroxide; water T=40°C; 2 h; 2: With hydrogenchloride in water T=5°C; pH=5; 3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite Product distribution / selectivity; more than 3 stages;
参考文献
WO2006/80401 A1, ;
Page/Page column 38-40 ;
反应条件
1: With sodium hydroxide; water
T=40°C; 2 h;
2: With hydrogenchloride in water
T=5°C; pH=5;
3: With hydrogenchloride; sodium hydroxide; sodium hypochlorite
Product distribution / selectivity; more than 3 stages;
参考文献
MITSUI CHEMICALS, INC.
Patent: WO2006/80401 A1, 2006 ;
Location in patent: Page/Page column 38-40 ;
