BOC-4-去氢-L-脯氨酸合成路线 （共 35 条）
反应条件
in diethyl ether T=-15 - 20°C;
参考文献
AMURA THERAPEUTICS LIMITED
Patent: WO2004/7501 A1, 2004 ;
Location in patent: Page 416-417 ;
WO 2004/007501 A1
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=80 - 90°C; 8 h;
参考文献
Synthesis, , # 9 p. 753 - 756
反应条件
1-propanephosphonic acid cyclic anhydride in ethyl acetate T=0°C; 3 h;
参考文献
CLARIANT GMBH
Patent: WO2005/123632 A1, 2005 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: in methanol; hexane; toluene T=0°C; 0.75 h; 2: With acetic acid in methanol; hexane; toluene Product distribution / selectivity;
参考文献
AMURA THERAPEUTICS LIMITED
Patent: WO2007/17698 A1, 2007 ;
Location in patent: Page/Page column 30-31 ;
反应条件
potassium hydrogencarbonate in acetone T=30 - 45°C; 5.25 - 6.33333 h; Heating / reflux; Product distribution / selectivity;
参考文献
AMURA THERAPEUTICS LIMITED
Patent: WO2007/17698 A1, 2007 ;
Location in patent: Page/Page column 37-38 ;
反应条件
tetrabutylammonium fluoride hydrofluoride in dichloromethane T=20°C; 2 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
1: With sodium tetrahydroborate; diphenyl diselenide in methanol 11 h; Heating; 2: With pyridine; dihydrogen peroxide in dichloromethane; water T=20°C; 2 h;
参考文献
Qiu, Xiao-Long; Qing, Feng-Ling
Journal of Organic Chemistry, 2005 , vol. 70, # 10 p. 3826 - 3837
反应条件
triethylsilane; tetrakis(triphenylphosphine) palladium(0)
参考文献
Pandey, Sushil K.; Orellana, Arturo; Greene, Andrew E.; Poisson, Jean-Francois
Organic Letters, 2006 , vol. 8, # 24 p. 5665 - 5668
反应条件
cesium fluoride in tert-butyl alcohol T=100°C; 7 h;
参考文献
Journal of Organic Chemistry, , vol. 73, # 20 p. 8106 - 8108
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=85°C; 3 h;
参考文献
Shangguan, Ning; Joullie, Madeleine
Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6748 - 6750
