1-(3,5-脱水-2-脱氧-Β-D-苏-戊呋喃糖基)胸腺嘧啶合成路线 （共 9 条）
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran; hexane T=-70°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 30, # 19 p. 2567 - 2570
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran; pentane T=-70°C; 1 h; Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 30, # 19 p. 2567 - 2570
反应条件
potassium hydroxide in tert-butyl alcohol T=55 - 60°C; 2 h;
参考文献
Paramashivappa; Phani Kumar; Subba Rao; Srinivasa Rao
Tetrahedron Letters, 2003 , vol. 44, # 5 p. 1003 - 1005
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran; hexane T=-70°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 30, # 19 p. 2567 - 2570
反应条件
boron trifluoride diethyl etherate in tetrahydrofuran; pentane T=-70°C; 1 h; Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 30, # 19 p. 2567 - 2570
反应条件
1: 85 percent / NaI, glacial HOAc / 0.5 h / Heating 2: toluene-4-sulphonic acid / CH2Cl2 3: AgOAc / acetonitrile / Heating 4: 75 percent / aq.HOAc / 2 h / Ambient temperature View Scheme
参考文献
Joshi; Reese
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2371 - 2374
反应条件
sodium hydroxide
0.75 h; Heating;
参考文献
Mansuri; Starrett Jr.; Ghazzouli; Hitchcock; Sterzycki; Brankovan; Lin; August; Prusoff; Sommadossi; Martin
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 461 - 466
反应条件
1: pyridine / 20 °C
2: aq. NaOH / methanol
View Scheme
参考文献
Chen, Shi-Wu; Wang, Yun-Hua; Jin, Yan; Tian, Xuan; Zheng, Yong-Tang; Luo, Du-Qiang; Tu, Yong-Qiang
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 2091 - 2095
反应条件
1: 70 percent / BF3*OEt2, LiBr / tetrahydrofuran / 2 h / -50 °C
2: 40 percent / 20 h / 140 °C
3: 98 percent / diethyl ether
4: 95 percent / pyridine, 4-(dimethylamino)pyridine / 24 h / 20 °C
5: 69 percent / LiN3 / dimethylformamide / 4 h / 95 °C
6: 75 percent / Me3SiBr / CH2Cl2 / 7 h / 25 °C
View Scheme
参考文献
Hakimelahi; Moosavi-Movahedi; Sadeghi; Tsay; Jih Ru Hwu
Journal of Medicinal Chemistry, 1995 , vol. 38, # 23 p. 4648 - 4659
