(1R,2S)-1-氨基-2-茚满醇合成路线 （共 78 条）
反应条件
in dichloromethane Inert atmosphereReflux;
参考文献
Chollet, Guillaume; Didier, Dorian; Schulz, Emmanuelle
Catalysis Communications, 2010 , vol. 11, # 5 p. 351 - 355
反应条件
in N,N-dimethyl-formamide T=23°C;
参考文献
Ghosh, Arun K.; Mathivanan, Packiarajan; Cappiello, John
Tetrahedron Letters, 1996 , vol. 37, # 22 p. 3815 - 3818
反应条件
N-isopropylcarbamoyl-derivatized cyclofructan-6 column in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Resolution of racemate;
参考文献
Verkuijl, Bastiaan J.V.; De Vries, Johannes G.; Feringa, Ben L.
Chirality, 2011 , vol. 23, # 1 p. 34 - 43
反应条件
1: triethylamine / toluene / 3 h / Reflux 2: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 °C 3: Arthrobacter sp. lipase / toluene / 25 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 4: water; hydrazine hydrate / 3 h / 60 °C View Scheme
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2134 - 2143
反应条件
sodium hydroxide; (p-cymene)-ruthenium(II) chloride dimer in isopropyl alcohol
T=20 - 85°C; 5 h;
参考文献
Lonza AG
Patent: WO2004/31168 A2, 2004 ;
Location in patent: Page 15 ;
反应条件
1: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h
2: 40 percent / trifluoroacetic acid / CHCl3 / 2.5 h
3: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating
4: 66 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, N-methylmorpholine / dimethylformamide / 17 h
5: 8.5 g / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h
6: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran; methanol / 96 h
7: 98.9 percent / Cs2CO3 / dioxane / 36 h / 80 °C
View Scheme
参考文献
Thompson; Fitzgerald; Holloway; Emini; Darke; McKeever; Schleif; Quintero; Zugay; Tucker; Schwering; Homnick; Nunberg; Springer; Huff
Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1685 - 1701
反应条件
in dichloromethane
T=20°C; 24 h;
参考文献
Marques-Lopez, Eugenia; Alcaine, Ana; Tejero, Tomas; Herrera, Raquel P.
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3700 - 3705
反应条件
1: Et3N / tetrahydrofuran
2: DEAD; PPh3
3: NaOMe / methanol
View Scheme
参考文献
Qiao, Jennifer X.; Wang, Tammy C.; Wang, Gren Z.; Cheney, Daniel L.; He, Kan; Rendina, Alan R.; Xin, Baomin; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y.S.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5041 - 5048
