(1R,2S)-1-氨基-2-茚满醇合成路线 （共 78 条）
反应条件
1: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 2: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 9 p. 1585 - 1587
反应条件
1: K2CO3 / methanol / 0.17 h / Ambient temperature 2: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 3: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 9 p. 1585 - 1587
反应条件
1: 39.9 percent / NaHCO3, mCPBA / CH2Cl2 / 24 h / Ambient temperature 2: 97.7 percent / NaN3, NH4Cl / dimethylformamide; H2O / 2 h / 80 °C 3: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 4: K2CO3 / methanol / 0.17 h / Ambient temperature 5: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 6: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 9 p. 1585 - 1587
反应条件
1: 97.7 percent / NaN3, NH4Cl / dimethylformamide; H2O / 2 h / 80 °C 2: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 3: K2CO3 / methanol / 0.17 h / Ambient temperature 4: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 5: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 9 p. 1585 - 1587
反应条件
1: 91 percent / Et3N / dimethylformamide / 1 h / Ambient temperature 2: 92 percent / SOCl2 / CH2Cl2 / 3 h / Ambient temperature 3: 92 percent / 20percent H2SO4 / CH2Cl2 / 10 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 10 p. 2060 - 2067
反应条件
1: 92 percent / SOCl2 / CH2Cl2 / 3 h / Ambient temperature 2: 92 percent / 20percent H2SO4 / CH2Cl2 / 10 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 10 p. 2060 - 2067
反应条件
1: 88 percent / aq. H2SO4 / H2O / 16 h / Heating 2: 97 percent / 1-hydroxybenzotriazole hydrate, dimethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, triethylamine / dimethylformamide / 16 h 3: 40 percent / trifluoroacetic acid / CHCl3 / 2.5 h 4: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1685 - 1701
反应条件
1: 40 percent / trifluoroacetic acid / CHCl3 / 2.5 h 2: 93 percent / 20percent aq. NaOH / ethanol / 16 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 10 p. 1685 - 1701
反应条件
1: 86 percent / SOCl2 / 12 h / 23 °C 2: 87 percent / aq. KOH / ethanol / 16 h / Heating View Scheme
参考文献
Synthesis, , # 5 p. 541 - 544
反应条件
hydrogen bromide; hydrogen; palladium
参考文献
Tetrahedron Letters, , vol. 39, # 43 p. 7921 - 7924
