(1R,2S)-1-氨基-2-茚满醇合成路线 （共 78 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.5 h;
参考文献
Takahashi, Michiyasu; Ogasawara, Kunio
Synthesis, 1996 , # 8 p. 954 - 958
反应条件
1: 68 percent / H2 / 10percent Pd/C / ethyl acetate / 12 h / 23 °C 2: 86 percent / SOCl2 / 12 h / 23 °C 3: 87 percent / aq. KOH / ethanol / 16 h / Heating View Scheme
参考文献
Synthesis, , # 5 p. 541 - 544
反应条件
1: 89.9 percent / NaOH / diethyl ether / 4 h / Ambient temperature 2: 93 percent / NaN3, NH4Cl / ethanol; H2O / 2 h / Heating 3: 48.1 percent / lipase PS-on-Celite (Pseudomonas sp., Amano), t-BuOMe / 55 h / Ambient temperature 4: 74.6 percent / Ph3P, diethyl azidocarboxylate / tetrahydrofuran / 2.5 h / Ambient temperature 5: 65.1 percent / LiAlH4 / tetrahydrofuran / 1.5 h View Scheme
参考文献
Synthesis, , # 8 p. 954 - 958
参考文献
Kawabata; Yamamoto; Momose; Yoshida; Nagaoka; Fuji
Chemical Communications, 2001 , # 24 p. 2700 - 2701
参考文献
Tetrahedron: Asymmetry, , vol. 6, # 1 p. 301 - 306
反应条件
sulfuric acid in acetonitrile T=50°C; 8 h;
参考文献
Nakano, Shigeru; Igarashi, Yoshio; Nohira, Hiroyuki
Tetrahedron Asymmetry, 2001 , vol. 12, # 1 p. 59 - 62
反应条件
1: PhIO, Mn((S,S)salen), 4-phenylpyridine-N-oxide / chlorobenzene / 4 h / 40 °C 2: CF3CO2H / tetrahydrofuran; H2O 3: HONH2, HCl 4: H2, HBr / Pd-black View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 43 p. 7921 - 7924
反应条件
1: CF3CO2H / tetrahydrofuran; H2O 2: HONH2, HCl 3: H2, HBr / Pd-black View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 43 p. 7921 - 7924
反应条件
1: 44.6 percent / 0.1M aq. phosphate buffer / acetone / lipase PS 2: 39.9 percent / NaHCO3, mCPBA / CH2Cl2 / 24 h / Ambient temperature 3: 97.7 percent / NaN3, NH4Cl / dimethylformamide; H2O / 2 h / 80 °C 4: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 5: K2CO3 / methanol / 0.17 h / Ambient temperature 6: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 7: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 9 p. 1585 - 1587
反应条件
1: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 2: K2CO3 / methanol / 0.17 h / Ambient temperature 3: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 4: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 43, # 9 p. 1585 - 1587
