(4-乙酰氧基-2,3,6-三甲基-苯基)乙酸酯合成路线 （共 23 条）
反应条件
acetic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 18 h; Product distribution / selectivity;
参考文献
Galileo Pharmaceuticals, Inc.
Patent: US2006/128790 A1, 2006 ;
Location in patent: Page/Page column 74-75 ;
反应条件
1: With methanetrisulfonic acid
T=25 - 100°C; 3.5 - 24 h;
2: With sodium carbonate
T=20°C; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2005/44775 A1, 2005 ;
Location in patent: Page/Page column 3-5 ;
反应条件
sulfuric acid; acetic acid
T=100°C; 3 h;
参考文献
Degussa AG
Patent: US6350897 B2, 2002 ;
Location in patent: Example 1 ;
反应条件
sulfuric acid
T=80°C; 5 h;
参考文献
Daicel Chemical Industries, Ltd.
Patent: US6369263 B1, 2002 ;
Location in patent: Example 1 ;
参考文献
Smith
Journal of the American Chemical Society, 1934 , vol. 56, p. 472
反应条件
indium(III) chloride
T=25 - 50°C; 18 - 76 h; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2005/58792 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
1: 1,1-dimethoxy-3,7-dimethylocta-2,6-diene; 2,3,5-trimethyl hydroquinone With pyridine
T=165 - 175°C; 4 h; Inert atmosphere;
2: acetic anhydride With pyridine
T=0 - 20°C; Inert atmosphere;
参考文献
Gembus, Vincent; Sala-Jung, Nathalie; Uguen, Daniel
Bulletin of the Chemical Society of Japan, 2009 , vol. 82, # 7 p. 843 - 854
反应条件
1: 2,3,5-trimethyl hydroquinone; C22H44O2 With pyridine
T=180°C; 2 h; Inert atmosphere;
2: acetic anhydride With pyridine
T=0 - 20°C; Inert atmosphere;
参考文献
Gembus, Vincent; Sala-Jung, Nathalie; Uguen, Daniel
Bulletin of the Chemical Society of Japan, 2009 , vol. 82, # 7 p. 843 - 854
反应条件
1: 2,3,5-trimethyl hydroquinone; (E/Z)-3,7-dimethylocta-2,7-dienal dimethyl acetal With pyridine
T=165°C; 24 h; Inert atmosphere;
2: acetic anhydride With pyridine
T=0 - 20°C; Inert atmosphere;
参考文献
Gembus, Vincent; Sala-Jung, Nathalie; Uguen, Daniel
Bulletin of the Chemical Society of Japan, 2009 , vol. 82, # 7 p. 843 - 854
反应条件
1: AcOH / CHCl3
2: BF3-Me2O
View Scheme
参考文献
Budzikiewicz,H.; Gunawan,J.
Monatshefte fuer Chemie, 1973 , vol. 104, p. 876 - 884
