3-氯-2-甲基乙酰苯胺合成路线 （共 29 条）
参考文献
Cohn,P.
Monatshefte fuer Chemie, 1901 , vol. 22, p. 485
反应条件
1: 65.7 percent / potassium permanganate; magnesium sulfate heptahydrate / H2O / 5 h / 135 - 160 °C 2: hydrochloric acid / 1.5 h / 80 - 90 °C View Scheme
参考文献
Huntress; Cliff
Journal of the American Chemical Society, 1933 , vol. 55, p. 2559,2563
反应条件
1: bromine; acetic acid / 4 h / 0 - 20 °C 2: magnesium sulphate heptahydrate; potassium permanganate / water / 3 h / |Reflux View Scheme
参考文献
Boettcher, Stephan; Hederos, Markus; Champion, Elise; Dekany, Gyula; Thiem, Joachim
Organic Letters, 2013 , vol. 15, # 14 p. 3766 - 3769
反应条件
1: 96 percent / bromine; glacial acetic acid / 2 h
2: 67 percent / dimethylformamide / 4 h / 150 °C
3: 95 percent / conc. HCl; EtOH / 0.5 h / Heating
4: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/14627 A1, 2013 ;
反应条件
1: 96 percent / bromine; glacial acetic acid / 2 h
2: 67 percent / dimethylformamide / 4 h / 150 °C
3: 95 percent / conc. HCl; EtOH / 0.5 h / Heating
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/14627 A1, 2013 ;
反应条件
1: Cl2 / acetic acid; CHCl3
2: conc. aq. HCl / aq. ethanol / 18 h / Heating
View Scheme
参考文献
Cason et al.
Journal of Organic Chemistry, 1951 , vol. 16, p. 328,330
反应条件
1: 96 percent / bromine; glacial acetic acid / 2 h
2: 67 percent / dimethylformamide / 4 h / 150 °C
View Scheme
参考文献
NOVARTIS AG; BOCK, Mark Gary; LAGU, Bharat; PANDIT, Chetan; SASMAL, Sanjita; ULLRICH, Thomas
Patent: WO2013/14627 A1, 2013 ;
反应条件
1: 65.7 percent / potassium permanganate; magnesium sulfate heptahydrate / H2O / 5 h / 135 - 160 °C
2: hydrochloric acid / 1.5 h / 80 - 90 °C
3: 67.6 percent / 2 h / 130 - 175 °C
4: 51.6 percent / H2SO4; nitric acid / 0.17 h / 0 °C
View Scheme
参考文献
Jin, Yi; Li, Hui-Yuan; Lin, Li-Ping; Tan, Jinzhi; Ding, Jian; Luo, Xiaomin; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 19 p. 5613 - 5622
反应条件
1: potassium permanganate; magnesium sulfate; water
2: aqueous hydrochloric acid
3: aqueous hydrochloric acid; sodium nitrite / Diazotization.Eintragen der erhaltenen Diazoniumsalz-Loesung in eine aus Kupfer(II)-sulfat, Schwefeldioxid und wss. Ammoniak hergestellte Loesung
View Scheme
参考文献
Huntress; Cliff
Journal of the American Chemical Society, 1933 , vol. 55, p. 2559,2563
