反应条件
1: 2-amino-benzonitrile With sodium methylate in 1,4-dioxane
Deprotonation;
2: N,N-diethylcyanamide in 1,4-dioxane
Cycloaddition; 16 h; Heating; Further stages.;
参考文献
Van Muijlwijk-Koezen, Jacqueline E.; Timmerman, Henk; Van Der Goot, Henk; Menge, Wiro M. P. B.; Von Drabbe Kuenzel, Jacobien Frijtag; De Groote, Miriam; Ijzerman, Adriaan P.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 11 p. 2227 - 2238
