2-(氯甲基)-4,6-二甲基嘧啶合成路线 (共 11 条)
反应条件
1: N,N-dimethyl-formamide / 4 h / 80 °C
2: sodium hydroxide; water / ethanol / 18 h / 80 °C
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参考文献
ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter
Patent: WO2011/151651 A1, 2011 ;
WO 2011/151651 A1