2-氟-4-甲氧基苯乙酮合成路线 （共 19 条）
反应条件
aluminium trichloride in carbon disulfide T=20 - 35°C;
参考文献
Hartmann; Heindl; Schwarz; Schonenberger
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 819 - 824
反应条件
lithium perchlorate T=100°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 43, # 36 p. 6331 - 6333
反应条件
1: 1.) Br2, aq. NaOH / 1.) 10 deg C, 2.) dioxane, RT, 1 h 2: LiAlH4 / diethyl ether / 1 h / Heating 3: HCl gas / benzene / 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 9 p. 2535 - 2544
反应条件
1: 1.) Br2, aq. NaOH / 1.) 10 deg C, 2.) dioxane, RT, 1 h 2: LiAlH4 / diethyl ether / 1 h / Heating View Scheme
参考文献
Gust, Ronald; Burgemeister, Thomas; Mannschreck, Albrecht; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2535 - 2544
反应条件
sodium hydroxide; bromine in water 2 h; Ambient temperature;
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
1: 66 percent / Br2, NaOH / H2O / 2 h / Ambient temperature 2: 89 percent / SOCl2 / Heating View Scheme
参考文献
Hartmann; Vom Orde; Schonenberger
Archiv der Pharmazie, 1990 , vol. 323, # 2 p. 73 - 78
反应条件
1.1: tetrahydrofuran / 1 h / -15 - 0 °C 2.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethanol; water / 1 h / 40 °C / 775.74 Torr 3.1: N-bromosuccinmide / acetonitrile / 35 °C 4.1: n-butyllithium / toluene; hexane; tetrahydrofuran / -80 - -35 °C / Inert atmosphere 4.2: Inert atmosphere 5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 24 h / 35 °C / Inert atmosphere 6.1: N,N-dimethyl-formamide; thionyl chloride / 5 h / 0 - 20 °C 7.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 1 h / -15 °C 7.2: -15 - 12 °C View Scheme
参考文献
LEK Pharmaceuticals d.d.
Patent: EP2468735 A1, 2012 ;
参考文献
Merck and Co., Inc.
Patent: US5847008 A1, 1998 ;
反应条件
hydrazine hydrate in ethanol; ethylene glycol
参考文献
Alcon, Inc.
Patent: US6956036 B1, 2005 ;
