4-甲氧基苯亚甲基丙二酸二甲酯合成路线 （共 11 条）
反应条件
recovered palladium catalyst in ethanol T=20°C; 18 h; Green chemistry;
参考文献
Wang, Hu; Li, Li; Bai, Xing-Feng; Deng, Wen-Hui; Zheng, Zhan-Jiang; Yang, Ke-Fang; Xu, Li-Wen
Green Chemistry, 2013 , vol. 15, # 9 p. 2349 - 2355
反应条件
Michael Addition; Alkaline conditions;
参考文献
Li, Yun; Zhou, Zhengquan; Ye, Weijian; Liu, Juanjuan; Yao, Juan; Wang, Cunde
Journal of Chemical Research, 2013 , vol. 37, # 9 p. 526 - 530
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Han, Jeng Liang; Ong, Chi Wi
Tetrahedron, 2005 , vol. 61, # 6 p. 1501 - 1507
反应条件
1: NaH / dimethylformamide / Ambient temperature 2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h 3: H2 / 10percent Pd/C / acetonitrile / 4 h / 2068.6 Torr 4: MeONa / methanol / 3 h / Heating 5: LiBr / dimethylformamide / 4 h / Heating 6: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, toluene, heating, 2 h View Scheme
参考文献
Kimball; Floyd; Das; Hunt; Krapcho; Rovnyak; Duff; Lee; Moquin; Turk; Hedberg; Moreland; Brittain; McMullen; Normandin; Cucinotta
Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 780 - 793
反应条件
piperidine; acetic acid in benzene
Knoevenagel Condensation; Dean-StarkRefluxInert atmosphere;
参考文献
Goldberg, Alexander F. G.; O'Connor, Nicholas R.; Craig, Robert A.; Stoltz, Brian M.
Organic Letters, 2012 , vol. 14, # 20 p. 5314 - 5317,4
Title/Abstract Show Details
Goldberg, Alexander F. G.; O'Connor, Nicholas R.; Craig, Robert A.; Stoltz, Brian M.
Organic Letters, 2012 , vol. 14, # 20 p. 5314 - 5317
反应条件
tri-n-butyl-antimony; copper(l) iodide in benzene
T=80°C; 6 h;
参考文献
Liao; Huang
Tetrahedron Letters, 1990 , vol. 31, # 41 p. 5897 - 5900
反应条件
pyridine in benzene
T=20°C; Heating; chemoselective reaction;
参考文献
Sidhu, Anjali; Rai, Mangat
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 5 p. 735 - 736
反应条件
1: With potassium tert-butylate; dirhodium tetraacetate in dichloromethane
T=20°C;
2: With trimethylamine-N-oxide
参考文献
Han, Jeng Liang; Ong, Chi Wi
Tetrahedron, 2005 , vol. 61, # 6 p. 1501 - 1507
参考文献
Druzgala, Pascal; Milner, Peter G.; Pfister, Jurg R.
Patent: US2003/236227 A1, 2003 ;
Location in patent: Page 3; sheet 22 ;
US 20030236227 A1
反应条件
1.1: copper(l) chloride / tetrahydrofuran / 1 h / 0 °C
2.1: potassium hydroxide / water / 3 h / Reflux
3.1: sulfuric acid / water / 8 h / Reflux
3.2: polyphosphoric acid / 1 h / 80 °C
4.1: hydrogen bromide / acetic acid / 6 h / Reflux
View Scheme
参考文献
Jung, Jae-Chul; Jang, Soyong; Oh, Seikwan; Park, Oee-Sook
Journal of Chemical Sciences, 2010 , vol. 122, # 6 p. 833 - 838
