反应条件
1: H2O, NaOH / methanol
2: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / formamide / 10 h. 0 deg C, 10 h. room temp.
3: H2O, NaOH / methanol
4: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
5: H2O, NaOH / methanol
6: N-hydroxybenzotriazole, triethylamine, dicyclohexylcarbodiimide / dimethylformamide
7: NH3 / methanol
8: HCl, acetic acid / various solvent(s) / 1.5 h
View Scheme
参考文献
Audigier; Mazarguil; Gout; Cros
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 2 p. 173 - 177