trans－13－二十二碳一烯酸甲酯合成路线 （共 9 条）
反应条件
1: 75 percent / HBr, HOAc / a) r.t., 16 h, b) 100 deg C, 4 h
2: 90 percent / NaI / acetone / 16 h / Heating
3: 89 percent / 4 h / Ambient temperature
5: 1.) lithium hexamethyldisilazide, hexamethylphosphoramide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h
View Scheme
参考文献
Kling, Marcel R.; Easton, Christopher J.; Poulos, Alf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 10 p. 1183 - 1190
反应条件
1: acetonitrile / 36 h / Heating
2: 1.) lithium hexamethyldisilazide, hexamethylphosphoramide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h
View Scheme
参考文献
Kling, Marcel R.; Easton, Christopher J.; Poulos, Alf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 10 p. 1183 - 1190
反应条件
1: 90 percent / NaI / acetone / 16 h / Heating
2: 89 percent / 4 h / Ambient temperature
4: 1.) lithium hexamethyldisilazide, hexamethylphosphoramide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h
View Scheme
参考文献
Kling, Marcel R.; Easton, Christopher J.; Poulos, Alf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 10 p. 1183 - 1190
参考文献
Plisow; Bulatowa
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 498,500;engl.Ausg.S.489,491
参考文献
Jantzen; Andreas
Chemische Berichte, 1959 , vol. 92, p. 1427,1430
反应条件
1: 89 percent / 4 h / Ambient temperature
3: 1.) lithium hexamethyldisilazide, hexamethylphosphoramide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h
View Scheme
参考文献
Kling, Marcel R.; Easton, Christopher J.; Poulos, Alf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 10 p. 1183 - 1190
反应条件
2: 1.) lithium hexamethyldisilazide, hexamethylphosphoramide / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h
View Scheme
参考文献
Kling, Marcel R.; Easton, Christopher J.; Poulos, Alf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 10 p. 1183 - 1190
反应条件
sodium methylate
Electrolysis;
参考文献
Bounds et al.
Journal of the Chemical Society, 1953 , p. 2393,2397
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium hexamethyldisilazane
1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kling, Marcel R.; Easton, Christopher J.; Poulos, Alf
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 10 p. 1183 - 1190
