4-哌啶-1-丁基-1-胺合成路线 （共 13 条）
反应条件
ammonium hydroxide; hydrogen; nickel in methanol; water T=20°C; P=3102.97 Torr; 24 h; Inert atmosphere;
参考文献
WYETH; SIENA BIOTECH S.P.A.
Patent: US2010/16598 A1, 2010 ;
Location in patent: Page/Page column 27 ;
反应条件
hydrazine in ethanol T=80°C; 4 h;
参考文献
SIENA BIOTECH S.P.A.
Patent: WO2006/8133 A2, 2006 ;
Location in patent: Page/Page column 18-19 ;
WO 2006/008133 A2
反应条件
xylene und Erhitzen des Reaktionsprodukts mit wss. Natronlauge und anschliessend mit wss.Salzsaeure;
参考文献
Journal of the American Chemical Society, , vol. 79, p. 4699,4702
反应条件
nickel T=100°C; P=73550.8 Torr; Hydrogenation;
参考文献
Journal of the American Chemical Society, , vol. 66, p. 725,728
反应条件
sodium hydroxide in diethyl ether
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5100889 A1, 1992 ;
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; Reduction; 1 h;
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
反应条件
1: K2CO3; KI / acetonitrile / 18 h / 20 °C 2: H2; NH3 / Raney-nickel / methanol / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 7 p. 1938 - 1940
反应条件
1: 51 percent / K2CO3 / methanol; H2O / Heating 2: 1.) BH3*(CH3)2S, 2.) HCl / 1) THF 3: 10percent K2CO3 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 49, p. 133 - 138
反应条件
1: 52 percent / NaH / tetrahydrofuran / 2 h / 20 °C 2: 51 percent / KOH / ethanol / 12 h / 0 °C 3: 28 percent / 0.25 h / 150 °C / 4 Torr 4: 60 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 28, # 22 p. 4257 - 4272
反应条件
1: 28 percent / 0.25 h / 150 °C / 4 Torr 2: 60 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 28, # 22 p. 4257 - 4272
