1: 60 percent / sodium iodide / N,N-dimethyl-acetamide / 4 h / 70 °C 2: 90 percent / CuBr2 / CHCl3; ethyl acetate / 2 h / Heating 3: 85 percent / aq. NaOH / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme