4-乙酰氨基-3-硝基苯乙酮合成路线 （共 10 条）
反应条件
1: aqueous hydrochloric acid 2: acetic acid; bromine 3: KHSO3; anhydrous nitric acid / 0 °C / Erhitzen des auf Eis gegossenen Reaktionsgemisches mit Aethanol und CuSO4 auf dem Dampfbad View Scheme
参考文献
Raadsveld
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 813,824
反应条件
1: aqueous hydrochloric acid 2: aqueous sulfuric acid; ethanol View Scheme
参考文献
Raadsveld
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 813,824
反应条件
Bi(NO3)3·5H2O in dichloromethane
T=23°C; regioselective reaction;
参考文献
Lu, Yang; Li, Yaming; Zhang, Rong; Jin, Kun; Duan, Chunying
Tetrahedron, 2013 , vol. 69, # 45 p. 9422 - 9427
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
hydrogen bromide; dihydrogen peroxide in dichloromethane; water
T=20°C; 15 h;
参考文献
Khan, Abu T.; Parvin, Tasneem; Choudhury, Lokman H.; Ghosh, Subrata
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2271 - 2274
反应条件
nitric acid; acetic anhydride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate
参考文献
Schering Corporation
Patent: US4512998 A1, 1985 ;
反应条件
1: 1 h / 30 °C
2: nitric acid / 1 h / 5 °C
View Scheme
参考文献
Blau, Lorena; Menegon, Renato Farina; Trossini, Gustavo H. G.; Molino, Joao Vitor Dutra; Vital, Drielli Gomes; Cicarelli, Regina Maria Barretto; Passerini, Gabriela Duo; Bosquesi, Priscila Longhin; Chin, Chung Man
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 142 - 151
参考文献
Raadsveld
Recueil des Travaux Chimiques des Pays-Bas, 1935 , vol. 54, p. 813,824
参考文献
Mayer; Stark; Schoen
Chemische Berichte, 1932 , vol. 65, p. 1333,1335
反应条件
hydrogenchloride
0.5 h; Heating;
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
