5-氟-N-(5-羟基己基)-2,4-二氧代嘧啶-1-甲酰胺合成路线 （共 5 条）
反应条件
sodium tetrahydroborate in methanol
T=5 - 10°C; 1.5 h;
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: 90.9 percent / pyridine / 3 h / 90 °C
2: 48.8 percent / 1.) pyridine, triethylamine / 1.) 5 deg C, 30 min.; 2.) 20 deg C, 30 min.
3: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C
4: 43.7 percent / NaBH4 / methanol / 1.5 h / 5 - 10 °C
View Scheme
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: 72.94 percent / toluene / 2 h / 60 - 110 °C
2: 90.9 percent / pyridine / 3 h / 90 °C
3: 48.8 percent / 1.) pyridine, triethylamine / 1.) 5 deg C, 30 min.; 2.) 20 deg C, 30 min.
4: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C
5: 43.7 percent / NaBH4 / methanol / 1.5 h / 5 - 10 °C
View Scheme
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C
2: 43.7 percent / NaBH4 / methanol / 1.5 h / 5 - 10 °C
View Scheme
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: 48.8 percent / 1.) pyridine, triethylamine / 1.) 5 deg C, 30 min.; 2.) 20 deg C, 30 min.
2: 51.1 percent / conc. HCl / methanol / 14 h / 30 °C
3: 43.7 percent / NaBH4 / methanol / 1.5 h / 5 - 10 °C
View Scheme
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
