3,4-二甲基哌嗪-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 180-181 ;
反应条件
1: With sodium tris(acetoxy)borohydride in dichloromethane; water
T=20°C; 3 h;
2: With sodium hydrogencarbonate in dichloromethane; water
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1621537 A1, 2006 ;
Location in patent: Page/Page column 33 ;
反应条件
sodium cyanoborohydride in methanol; acetic acid
T=25 - 80°C; 10 h;
参考文献
CHIRON CORPORATION
Patent: WO2004/18419 A2, 2004 ;
Location in patent: Page 339-340 ;
反应条件
1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
2: sodium cyanoborohydride; acetic acid / methanol / 10 h / 25 - 80 °C
View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
2: sodium cyanoborohydride; acetic acid / methanol / 10 h / 25 - 80 °C
View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
