4-乙酰氨基-3-氯苯甲酸合成路线 （共 6 条）
反应条件
Oxonereg;; sodium carbonate; sodium bromide in methanol; water T=20°C; 24 h;
参考文献
Koo, Bon-Suk; Kim, Eun-Hoo; Lee, Kee-Jung
Synthetic Communications, 2002 , vol. 32, # 15 p. 2275 - 2286
参考文献
Schmelkes; Rubin
Journal of the American Chemical Society, 1944 , vol. 66, p. 1631
反应条件
oxygen; anhydrous cobalt diacetate; sodium bromide in acetic acid
T=100°C; 1.33333 h;
参考文献
Shcherbina, F. F.; Tmenov, D. N.; Lysukho, T. V.; Belous, N. P.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, p. 340 - 342
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 2 p. 381 - 384
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US6531474 B1, 2003 ;
US 6531474 B1
反应条件
chlorine in acetic acid
T=20 - 25°C; Title compound not separated from byproducts;
参考文献
Shchel'tsyn, V. K.; Frolova, T. I.; Grudtsyn, Yu. D.; Vandysheva, E. A.; Kaminskii, A. Ya.; Leonova, V. V.
Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 11.2 p. 2132 - 2142
Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 11 p. 2401 - 2412
反应条件
1: 99 percent / 0.67 h
2: 84 percent / KMnO4
View Scheme
参考文献
Dias, Marylene; Gibson, Mandy; Grimshaw, James; Hill, Ian; Trocha-Grimshaw, Jadwiga; Hammerich, Ole
Acta Chemica Scandinavica, 1998 , vol. 52, # 5 p. 549 - 554
