N-(2-溴-4,5-二甲氧基苯基)-N-乙基乙酰胺合成路线 （共 10 条）
反应条件
copper diacetate; palladium diacetate; sodium t-butanolate in toluene 24 h; Inert atmosphereReflux;
参考文献
Harada, Rika; Nishida, Naoto; Uchiito, Shiho; Onozaki, Yu; Kurono, Nobuhito; Senboku, Hisanori; Masao, Tokuda; Ohkuma, Takeshi; Orito, Kazuhiko
European Journal of Organic Chemistry, 2012 , # 2 p. 366 - 379
反应条件
1: 74 percent / sodium hydride, cuprous iodide / dimethylformamide / 1.) room temperature, 30 min, 2.) 80 - 85 deg C, 12 h 2: 64.7 percent / manganese dioxide / CH2Cl2 / 48 h / Ambient temperature 3: 72.6 percent / Claisen's alkali / 1 h / Heating View Scheme
参考文献
Kametani, Tetsuji; Ohsawa, Tatsushi; Ihara, Masataka
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 290 - 294
反应条件
bromine in acetic acid
2 h; Ambient temperature;
参考文献
Kametani, Tetsuji; Ohsawa, Tatsushi; Ihara, Masataka
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 290 - 294
反应条件
1: 96 percent / Et3N, DMAP / CH2Cl2 / Ambient temperature
2: 88 percent / Br2 / acetic acid / 6 h / Ambient temperature
View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
反应条件
1: 60 percent / Et3N, DMAP / CH2Cl2 / Heating
2: 95 percent / n-BuLi / tetrahydrofuran; hexane / a) 0 deg C, 75 min, b) RT, overnight
3: 88 percent / Br2 / acetic acid / 6 h / Ambient temperature
View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
反应条件
1: 94 percent / n-BuLi / tetrahydrofuran; hexane / a) 0 deg C, 75 min, b) RT, overnight
2: 88 percent / Br2 / acetic acid / 6 h / Ambient temperature
View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
反应条件
1: 95 percent / n-BuLi / tetrahydrofuran; hexane / a) 0 deg C, 75 min, b) RT, overnight
2: 88 percent / Br2 / acetic acid / 6 h / Ambient temperature
View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
参考文献
Martinez, Elena; Estevez, Juan C; Estevez, Ramon J; Castedo, Luis
Tetrahedron, 2001 , vol. 57, # 10 p. 1981 - 1986
参考文献
Martinez, Elena; Estevez, Juan C; Estevez, Ramon J; Castedo, Luis
Tetrahedron, 2001 , vol. 57, # 10 p. 1981 - 1986
参考文献
Martinez, Elena; Estevez, Juan C; Estevez, Ramon J; Castedo, Luis
Tetrahedron, 2001 , vol. 57, # 10 p. 1981 - 1986
