S(+)-γ-Vigabatrin合成路线 （共 29 条）
反应条件
hydrogenchloride; acetic acid in water
T=60°C; 12 h;
参考文献
Gnamm, Christian; Franck, Geraldine; Miller, Nicole; Stork, Timon; Broedner, Kerstin; Helmchen, Guenter
Synthesis, 2008 , # 20 p. 3331 - 3350
反应条件
potassium hydroxide in water; isopropyl alcohol
24 h; Heating;
参考文献
Wei, Zhong-Yong; Knaus, Edward E.
Tetrahedron, 1994 , vol. 50, # 19 p. 5569 - 5578
反应条件
1: With sodium naphthalenide in tetrahydrofuran
T=0°C; 2 h;
2: With hydrogenchloride
T=20°C; Further stages.;
参考文献
Chang, Meng-Yang; Lin, Chun-Yu; Ong, Chi-Wi
Heterocycles, 2006 , vol. 68, # 10 p. 2031 - 2036
反应条件
hydrogenchloride; triethylamine in ethanol; water; isopropyl alcohol
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US4621145 A1, 1986 ;
反应条件
trimethylsilyl iodide in dichloromethane
a) 0 deg C, 4 h, b) room temperature, 8 h; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Wei, Zhong-Yong; Knaus, Edward E.
Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1586 - 1588
反应条件
hydrazine hydrate in tetrahydrofuran; methanol
参考文献
Paul Raj, I. Victor; Sudalai
Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2646 - 2648
反应条件
hydrogenchloride
T=90°C; 5 h;
参考文献
Kwon; Keusenkothen; Smith
Journal of Organic Chemistry, 1992 , vol. 57, # 23 p. 6169 - 6173
反应条件
hydrogenchloride; acetic acid
T=60°C; 12 h;
参考文献
Dagoneau; Tomassini; Denis; Vallee
Synthesis, 2001 , # 1 p. 150 - 154
反应条件
hydrogenchloride
T=100°C;
参考文献
Anderson, Carolyn E.; Overman, Larry E.
Journal of the American Chemical Society, 2003 , vol. 125, # 41 p. 12412 - 12413
反应条件
1: 95 percent / DBU / CH2Cl2 / 2 h / 0 - 20 °C
2: [(S)-substituted-Cp-(Ph4-cyclobutadienyl)cobalt]dipalladium / CH2Cl2 / 18 h / 20 °C
3: aq. HCl / 100 °C
View Scheme
参考文献
Anderson, Carolyn E.; Overman, Larry E.
Journal of the American Chemical Society, 2003 , vol. 125, # 41 p. 12412 - 12413
