4-(苯基亚磺酰基)苯甲酸合成路线 （共 7 条）
反应条件
sodium hypochlorite T=20°C; 24 h;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 109 ;
WO 2010/115736 A2
反应条件
1: With aminosulfonic acid in water; acetone
T=0°C; 0.0833333 h;
2: With sodium chlorite in water; acetone
0.5 h;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 109 ;
WO 2010/115736 A2
反应条件
pyridine; phenyltrimethylammonium tribromide
18 h; Ambient temperature;
参考文献
Rabai, Jozsef; Kapovits, Istvan; Tanacs, Bela; Tamas, Jozsef
Synthesis, 1990 , # 9 p. 847 - 849
反应条件
potassium tert-butylate; oxygen in dimethyl sulfoxide; tert-butyl alcohol
参考文献
Russell,G.A. et al.
Journal of the American Chemical Society, 1962 , vol. 84, p. 2652 - 2653
反应条件
1: potassium carbonate / dimethyl sulfoxide / 12 h / 140 °C
2: water; lithium hydroxide hydrate / methanol; tetrahydrofuran / 4 h / 20 °C
3: phenyltrimethylammonium tribromide; pyridine; water / 12 h / 20 °C
View Scheme
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
反应条件
1: potassium carbonate / dimethyl sulfoxide / 12 h / 140 °C
2: water; lithium hydroxide hydrate / methanol; tetrahydrofuran / 4 h / 20 °C
3: phenyltrimethylammonium tribromide; pyridine; water / 12 h / 20 °C
View Scheme
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
反应条件
1: water; lithium hydroxide hydrate / methanol; tetrahydrofuran / 4 h / 20 °C
2: phenyltrimethylammonium tribromide; pyridine; water / 12 h / 20 °C
View Scheme
参考文献
CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.
Patent: WO2013/75083 A1, 2013 ;
