3-(5-氟-1H-吲哚-3-基)丙酸合成路线 （共 9 条）
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran
参考文献
Bristol-Myers Squibb Co.
Patent: US5077293 A1, 1991 ;
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran; water
参考文献
Fabre-Kramer Pharmaceuticals, Inc.
Patent: US2009/281114 A1, 2009 ;
US 20090281114 A1
反应条件
acetic anhydride in acetic acid
T=90°C; 42 h;
参考文献
Bristol-Myers Squibb Company
Patent: US5434154 A1, 1995 ;
US 5434154 A
反应条件
sodium hydroxide in ethanol
1 h; Heating;
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 1.) 12 M HCl, NaNO2, 2.) 6 M KOH, 3.) H2SO4
2: 6 M NaOH / ethanol / 1 h / Heating
3: 1 M HCl / 1.5 h / Heating
4: Cu2Cr2O5 / quinoline / 2 h / Heating
5: 6 M NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 1 M HCl / 1.5 h / Heating
2: Cu2Cr2O5 / quinoline / 2 h / Heating
3: 6 M NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 1.) 12 M HCl, NaNO2, 2.) 6 M KOH, 3.) H2SO4
2: 6 M NaOH / ethanol / 1 h / Heating
3: 1 M HCl / 1.5 h / Heating
4: Cu2Cr2O5 / quinoline / 2 h / Heating
5: 6 M NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: Cu2Cr2O5 / quinoline / 2 h / Heating
2: 6 M NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
反应条件
1: 6 M NaOH / ethanol / 1 h / Heating
2: 1 M HCl / 1.5 h / Heating
3: Cu2Cr2O5 / quinoline / 2 h / Heating
4: 6 M NaOH / ethanol / 1 h / Heating
View Scheme
参考文献
Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648
