1-苄基-4-(Boc-氨基)哌啶合成路线 （共 12 条）
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
IMPERIAL INNOVATIONS LIMITED; EMORY UNIVERSITY; BROWN, Robert; FUCHTER, Matthew John; CHAPMAN-ROTHE, Nadine; SRIMONGKOLPITHAK, Nitipol; CARON, Joachim; SYNDER, James; GANESH, Thota; LIU, Jin; SUN, Aiming
Patent: WO2013/140148 A1, 2013 ;
Location in patent: Page/Page column 65 ;
反应条件
sodium carbonate in 1-dioxane-water; water
反应条件
in chloroform; Petroleum ether
反应条件
water; sodium t-butanolate in tetrahydrofuran Heating;
参考文献
Tom, Norma J.; Simon, Wendy M.; Frost, Heather N.; Ewing, Marcus
Tetrahedron Letters, 2004 , vol. 45, # 5 p. 905 - 906
反应条件
1.1: 258 g / H2 / Pd/C / tetrahydrofuran; methanol / 4 h / 30 °C / 3420.23 - 3800.26 Torr 2.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 2.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C 3.1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 4.1: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: 258 g / H2 / Pd/C / tetrahydrofuran; methanol / 4 h / 30 °C / 3420.23 - 3800.26 Torr 2.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 2.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 72 h; Reflux;
参考文献
IMPERIAL INNOVATIONS LIMITED; EMORY UNIVERSITY; BROWN, Robert; FUCHTER, Matthew John; CHAPMAN-ROTHE, Nadine; SRIMONGKOLPITHAK, Nitipol; CARON, Joachim; SYNDER, James; GANESH, Thota; LIU, Jin; SUN, Aiming
Patent: WO2013/140148 A1, 2013 ;
Location in patent: Page/Page column 65 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol 12 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CRYSTALGENOMICS, INC.
Patent: WO2007/52938 A1, 2007 ;
Location in patent: Page/Page column 18 ;
WO 2007/052938 A1
