4-(溴甲基)吡啶氢溴酸盐合成路线 （共 10 条）
反应条件
phosphorus tribromide in chloroform 3 h; Heating;
参考文献
Anders; Opitz; Bauer
Synthesis, 1991 , # 12 p. 1221 - 1227
反应条件
phosphorus pentabromide in chloroform
参考文献
SmithKline Beecham Corporation
Patent: US6403792 B1, 2002 ;
反应条件
sodium hydrogencarbonate in diethyl ether; water
参考文献
Campbell, Jeffrey Allen; D'Andrea, Stanley; Good, Andrew; Li, Jianqing; Mcphee, Fiona; Ripka, Amy; Scola, Paul Michael; Tu, Yong
Patent: US2004/77551 A1, 2004 ;
Location in patent: Page/Page column 64 ;
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide T=60°C;
参考文献
Moorthy, Jarugu Narasimha; Neogi, Ishita
Tetrahedron Letters, 2011 , vol. 52, # 30 p. 3868 - 3871
反应条件
1: toluene 2: aqueous HBr View Scheme
参考文献
Bixler; Niemann
Journal of Organic Chemistry, 1958 , vol. 23, p. 575,580
Full Text Show Details
Zymalkowski
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 436,441
反应条件
sodium hydroxide in ethanol; water
参考文献
Bacque, Eric; Bigot, Antony; Carry, Jean-Christophe; Mignani, Serge; Ronan, Baptiste; Tabart, Michel
Patent: US2003/153605 A1, 2003 ;
参考文献
Bixler; Niemann
Journal of Organic Chemistry, 1958 , vol. 23, p. 575,580
Full Text Show Details
Zymalkowski
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 436,441
反应条件
sodium hydride in ethanol
T=25°C; 48 h;
参考文献
Braga, Fernanda Gambogi; Coimbra, Elaine Soares; de Oliveira Matos, Magnum; Lino Carmo, Arturene Maria; Cancio, Marisa Damato; da Silva, Adilson David
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 4 p. 530 - 537
反应条件
1: 5-fluoro-1H-indole-2-carboxylic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
2: 4-(bromomethyl)pyridine hydrobromide in N,N-dimethyl-formamide
T=0 - 20°C; 21.5 h;
参考文献
SANOFI-AVENTIS
Patent: US2008/146646 A1, 2008 ;
Location in patent: Page/Page column 7; 8 ;
参考文献
Anders; Opitz; Bauer
Synthesis, 1991 , # 12 p. 1221 - 1227
