1-甲氧基-4-苯基乙炔苯合成路线 （共 169 条）
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); triphenylphosphine in N,N-dimethyl-formamide
T=90°C; 2 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Jadhav, Deepak N.; Dasgupta, Priyabrata
Organic Letters, 2010 , vol. 12, # 9 p. 2048 - 2051
反应条件
1.1: magnesium / Inert atmosphere
1.2: Inert atmosphere
2.1: Jone's reagent
3.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere
3.2: 2 h / -98 - -60 °C / Inert atmosphere
3.3: Inert atmosphere
4.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
5.1: diisopropyl-carbodiimide / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
1,3-dimethyl-imidazolidin-2-one; potassium carbonate; triphenylphosphine; copper(l) chloride
T=120°C; 12 h; Reagent/catalyst;
参考文献
Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 518 - 521
反应条件
1,3-dimethyl-imidazolidin-2-one; potassium carbonate; triphenylphosphine; copper(l) chloride
T=120°C; 12 h;
参考文献
Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 518 - 521
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; palladium dichloride; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in dimethyl sulfoxide
T=120°C; 24 h; Inert atmosphere;
参考文献
Li, Xiang; Yang, Fan; Wu, Yangjie
RSC Advances, 2014 , vol. 4, # 26 p. 13738 - 13741
反应条件
palladium diacetate; dimethyl sulfoxide
T=35°C; Sonogashira Cross-Coupling; 1.5 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 598 - 605
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tributyl-amine; potassium carbonate in water
1.5 h; Ambient temperature;
参考文献
Bumagin; Sukhomlinova; Luzikova; Tolstaya; Beletskaya
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 7 p. 996 - 1000
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; cross-coupling;
参考文献
Nishihara, Yasushi; Ikegashira, Kazutaka; Hirabayashi, Kazunori; Ando, Jun-Ichi; Mori, Atsunori; Hiyama, Tamejiro
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1780 - 1787
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; cross-coupling;
参考文献
Nishihara, Yasushi; Ikegashira, Kazutaka; Hirabayashi, Kazunori; Ando, Jun-Ichi; Mori, Atsunori; Hiyama, Tamejiro
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1780 - 1787
反应条件
palladium diacetate; triphenylphosphine in N,N-dimethyl acetamide
T=80°C; P=760 Torr; 1 h;
参考文献
Kakusawa, Naoki; Kurita, Jyoji
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 699 - 702
