2-氧代-2-(4-(三氟甲基)苯基)乙酸乙酯合成路线 （共 4 条）
反应条件
1: 1-trifluoromethyl-4-bromobenzene With n-butyllithium in diethyl ether; hexane
T=-60 - 20°C;
2: oxalic acid diethyl ester in diethyl ether; hexane
参考文献
Brana, Miguel F.; Cacho, Monica; Garcia, M. Luisa; Mayoral, Elena P.; Lopez, Berta; De Pascual-Teresa, Beatriz; Ramos, Ana; Acero, Nuria; Llinares, Francisco; Munoz-Mingarro, Dolores; Lozach, Olivier; Meijer, Laurent
Journal of Medicinal Chemistry, 2005 , vol. 48, # 22 p. 6843 - 6854
反应条件
potassium fluoride; tetrabutyl ammonium fluoride; methyl iodide in tetrahydrofuran
T=20°C; 16 h; Inert atmosphere; chemoselective reaction;
参考文献
Metz, Alison E.; Kozlowski, Marisa C.
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 717 - 722
反应条件
in diethyl ether
T=-78 - 10°C;
参考文献
Creary, Xavier
Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 5026 - 5030
反应条件
1: 1-trifluoromethyl-4-bromobenzene With magnesium in diethyl ether
2: oxalic acid diethyl ester in diethyl ether
T=-78°C;
参考文献
Hewawasam, Piyasena; Erway, Matthew; Thalody, George; Weiner, Harvey; Boissard, Christopher G.; Gribkoff, Valentin K.; Meanwell, Nicholas A.; Lodge, Nicholas; Starrett, Jr, John E.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1117 - 1120
