1: 4-chloro pyridine hydrochloride With sodium hydroxide in tetrahydrofuran; water 2: With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 3: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - 20°C;
参考文献
ASAHI KASEI PHARMA CORPORATION
Patent: US2010/29733 A1, 2010 ;
Location in patent: Page/Page column 68-69 ;
US 20100029733 A1
1: 4-chloro pyridine hydrochloride in dichloromethane; water 0.25 h; 2: 3,4,5-trimethoxyphenylboronic acid With iron sulphate heptahydrate; dipotassium peroxodisulfate in dichloromethane; water T=20°C; 5 h; 3: With sodium hydroxide in dichloromethane; water T=20°C; Overall yield = 72 percent;
参考文献
Komeyama, Kimihiro; Nagao, Yuya; Abe, Manabu; Takaki, Ken
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 2 p. 301 - 313
1: benzyl alcohol With sodium hydride in N,N-dimethyl-formamide; mineral oil T=5°C; 0.25 h; 2: 4-chloro pyridine hydrochloride in N,N-dimethyl-formamide; mineral oil T=5 - 60°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2011/275627 A1, 2011 ;
Location in patent: Page/Page column 60 ;
