2-甲硫基-5-嘧啶羧酸乙酯合成路线 （共 16 条）
反应条件
hydrogen; sodium hydrogencarbonate; palladium 10 on activated carbon in ethanol 48 h;
参考文献
METHYLGENE INC.
Patent: US2008/227826 A1, 2008 ;
Location in patent: Page/Page column 27-28 ;
US 20080227826 A1
反应条件
1: (EtO)2CHCH2CO2H With sodium hydride; formic acid ethyl ester in diethyl ether; ethanol T=0 - 20°C; 15 h; 2: 2-methyl-2-thiopseudourea sulfate With sodium acetate in N,N-dimethyl-formamide T=85°C; 48 h;
参考文献
WO2007/55942 A2, ;
Page/Page column 63-65 ;
反应条件
1: β,β-diethoxypropionic acid ethyl ester; formic acid ethyl ester With sodium hydride in diethyl ether; ethanol T=0 - 20°C; 15 h; 2: 2-methyl-2-thiopseudourea sulfate With sodium acetate in N,N-dimethyl-formamide T=85°C; 48 h;
参考文献
US2009/105264 A1, ;
Page/Page column 33 ;
US 20090105264 A1
反应条件
acetic acid; zinc in tetrahydrofuran Reflux; Overall yield = 3.47 g;
参考文献
US2013/79313 A1, ;
Paragraph 1022 ;
反应条件
sodium acetate in N,N-dimethyl-formamide T=80 - 90°C; 12 h;
参考文献
Sansebastiano; Mosti; Menozzi; Schenone; Muratore; Petta; Debbia; Pesce Schito; Schito
Farmaco, 1993 , vol. 48, # 3 p. 335 - 355
反应条件
sodium ethanolate in ethanol 6 h; Heating;
参考文献
Arukwe, Joseph; Undheim, Kjell
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 9 p. 764 - 767
反应条件
1: S-methylisothiourea sulfate With sodium ethanolate in ethanol T=20°C; 0.5 h; 2: 3-(N,N-dimethylamino)-2-ethoxycarbonylacrolein in ethanol 0.5 h; Heating; Further stages.;
参考文献
Yu-Xiu, Liu; Ming-Bo, Cui; Qi-Qi, Zhao; Qing-Min, Wang; Ying, Liu; Run-Qiu, Huang
Journal of Chemical Research, 2007 , # 8 p. 490 - 493
反应条件
Condensation; cyclization;
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 98 percent / ethanolic KOH / 0.25 h / Ambient temperature 2: 76 percent / thionyl chloride / 2 h / Heating 3: 70 percent / manganese(II) iodide / diethyl ether; tetrahydrofuran / 4 h / -80 °C 4: 67 percent / m-chloroperbenzoic acid / CH2Cl2 / 2.5 h / Ambient temperature View Scheme
参考文献
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 40, # 9 p. 764 - 767
反应条件
1: aq. KOH 2: 69 percent / POCl3 View Scheme
参考文献
Arukwe, Joseph; Undheim, Kjell
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1986 , vol. 40, # 9 p. 764 - 767
