2-氟-1-(4-甲氧基苯基)乙酮合成路线 （共 18 条）
反应条件
potassium fluoride; ZnF2; tetrabutyl ammonium fluoride in acetonitrile
T=80°C; 10 h;
参考文献
Chen, Zizhan; Zhu, Wei; Zheng, Zubiao; Zou, Xinzhuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 3 p. 340 - 344
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in methanol
24 h; RefluxInert atmosphere;
参考文献
Nique, Francois; Robin-Jagerschmidt, Catherine; Clement-Lacroix, Philippe
Patent: US2010/63120 A1, 2010 ;
Location in patent: Page/Page column 64 ;
反应条件
4 A molecular sieve; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=-10°C; 8 h;
参考文献
Peng, Weimin; Shreeve, Jean'ne M.
Journal of Organic Chemistry, 2005 , vol. 70, # 14 p. 5760 - 5763
反应条件
1: With 1,3-Dichloro-5,5-dimethyl-2,4-imidazolidinedione; trimethyl-(2-hydroxyethyl)ammonium chloride; toluene-4-sulfonic acid in acetonitrile
T=20°C; 1 h; Inert atmosphere;
2: With ZnF2; tetrabutyl ammonium fluoride in acetonitrile
T=80°C; 8 h; Inert atmosphere;
参考文献
Chen, Zizhan; Zhu, Wei; Zheng, Zubiao; Zou, Xinzhuo
Journal of Fluorine Chemistry, 2010 , vol. 131, # 3 p. 340 - 344
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in methanol
24 h; Heating;
参考文献
Katoch-Rouse, Reeti; Pavlova, Olga A.; Caulder, Tara; Hoffman, Alexander F.; Mukhin, Alexey G.; Horti, Andrew G.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 642 - 645
反应条件
hydroxymethanesulfinic acid sodium salt in ethanol
0.75 h; Heating;
参考文献
Barkakaty, Balaka; Takaguchi, Yutaka; Tsuboi, Sadao
Tetrahedron, 2007 , vol. 63, # 4 p. 970 - 976
反应条件
methanol; Au(Ph3P)+NTf2-; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate)
T=70°C; 17 h;
参考文献
De Haro, Teresa; Nevado, Cristina
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 16 p. 2767 - 2772
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile
T=20°C;
参考文献
Fuglseth, Erik; Thvedt, Thor Hakon Krane; Moll, Maria Forde; Hoff, Bard Helge
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7318 - 7323
反应条件
tetrabutylammonium hydrogen bifluoride in tetrahydrofuran
Heating;
参考文献
Fuglseth, Erik; Thvedt, Thor Hakon Krane; Moll, Maria Forde; Hoff, Bard Helge
Tetrahedron, 2008 , vol. 64, # 30-31 p. 7318 - 7323
反应条件
1: With Au(Ph3P)+NTf2-; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate)
T=70°C;
2: With triethylamine
参考文献
De Haro, Teresa; Nevado, Cristina
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 16 p. 2767 - 2772
