反应条件
1: 2-methoxy-4-bromophenol With tert.-butyl lithium in tetrahydrofuran; diethyl ether; pentane
T=-78°C; 0.5 h;
2: With zinc(II) chloride in tetrahydrofuran
T=-78 - 20°C;
3: p-trifluoromethanesulfonyloxytoluene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; palladium diacetate in tetrahydrofuran
T=20°C; Negishi coupling reaction; 2 h;
参考文献
Shimizu, Haruka; Manabe, Kei
Tetrahedron Letters, 2006 , vol. 47, # 33 p. 5927 - 5931
