5-氨基-1-(2-羟乙基)吡唑合成路线 （共 6 条）
反应条件
in methanol; dichloromethane 4 h; Heating;
参考文献
Jachak, Madhukar; Kriessmann, Ulrike; Mittelbach, Martin; Junek, Hans
Monatshefte fuer Chemie, 1993 , vol. 124, p. 199 - 208
反应条件
formic acid; acetic anhydride in tetrahydrofuran; water; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4952578 A1, 1990 ;
反应条件
acetic anhydride T=30 - 40°C; 1 h;
参考文献
Ohki, Hidenori; Kawabata, Kohji; Inamoto, Yoshiko; Okuda, Shinya; Kamimura, Toshiaki; Sakane, Kazuo
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1685 - 1694
反应条件
hydrogenchloride in ethanol; water T=20°C; 17 h;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.; WAKUNAGA PHARMACEUTICAL CO., LTD.
Patent: WO2004/39814 A1, 2004 ;
Location in patent: Page 54 ;
反应条件
formic acid; acetic anhydride in tetrahydrofuran; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4952578 A1, 1990 ;
反应条件
acetic anhydride 1.) 40 deg C, 45 min, 2.) RT, 30 min; Multistep reaction;
参考文献
Ohki, Hidenori; Kawabata, Kohji; Inamoto, Yoshiko; Okuda, Shinya; Kamimura, Toshiaki; Sakane, Kazuo
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1685 - 1694
