6-甲氧基-2,3-二氢-5-甲酰基茚合成路线 （共 6 条）
反应条件
trichlorophosphate in N,N-dimethyl-formamide
参考文献
Beight, Douglas Wade; Kinnick, Michael Dean; Lin, Ho-Shen; Morin, John Michael; Richett, Michael Enrico; Sall, Daniel Jon; Sawyer, Jason Scott; Smith, Edward C R
Patent: US2004/77704 A1, 2004 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 0.5 h; 2: 2,3-dihydro-5-methoxy-1H-indene T=80°C; Vilsmeier reaction; 4 h;
参考文献
Sawyer, J. Scott; Beight, Douglas W.; Smith, Edward C. R.; Snyder, David W.; Chastain, Marcia K.; Tielking, Richard L.; Hartley, Lawrence W.; Carlson, Donald G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 893 - 896
参考文献
Journal of the American Chemical Society, , vol. 77, p. 2466,2471
反应条件
potassium permanganate; acetone
参考文献
Hunsberger et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 2466,2471
反应条件
1: KMnO4; aqueous acetone
2: HBr; acetic acid
3: acetic acid; bromine
4: quinoline / 180 °C
5: aqueous NaOH; acetone
6: magnesium; orthoformic acid triethyl ester; aqueous HCl
View Scheme
参考文献
Hunsberger et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 2466,2471
反应条件
1: 53 percent / NaOEt / diethyl ether; ethanol / 3 h / -10 - 20 °C
2: 52 percent / toluene / 6 h / Heating
View Scheme
参考文献
Sawyer, J. Scott; Beight, Douglas W.; Smith, Edward C. R.; Snyder, David W.; Chastain, Marcia K.; Tielking, Richard L.; Hartley, Lawrence W.; Carlson, Donald G.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 893 - 896
