乌非拉唑合成路线

220757-74-45-甲氧基-2-{[(4-氯-3,5-二甲基-吡啶-2-基)甲基]硫代}-1H-苯并咪唑→73590-85-9乌非拉唑

参考文献

Kuraray Co., Ltd.
Patent: US6197962 B1, 2001 ;

37052-78-12-巯基-5-甲氧基苯并咪唑+86604-75-32-氯甲基-3,5-二甲基-4-甲氧基吡啶盐酸盐→73590-85-9乌非拉唑

参考文献

ORCHID CHEMICALS and PHARMACEUTICALS LTD; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; SIVADAS, Anand; VIGNESWARA CHELLAM, Ravisankar; SHANMUGA SUNDARAM, Bharani Kumar; SUBBAIAH, Ramesh
Patent: WO2011/12957 A1, 2011 ;
Location in patent: Page/Page column 16 ;

142885-91-45-甲氧基-2-(((3,5-二甲基-4-硝基-2-吡啶)甲基)硫代)-1H-苯并咪唑+124-41-4甲醇钠→73590-85-9乌非拉唑

参考文献

US2007/82929 A1, ;

Page/Page column 42 ;
US 20070082929 A1

37052-78-12-巯基-5-甲氧基苯并咪唑+86604-78-64-甲氧基-3,5-二甲基-2-羟甲基吡啶→73590-85-9乌非拉唑

参考文献

WO2004/35565 A1, ;

Page 5; 8-9 ;

142885-91-45-甲氧基-2-(((3,5-二甲基-4-硝基-2-吡啶)甲基)硫代)-1H-苯并咪唑→73590-85-9乌非拉唑

参考文献

Cipla Limited
Patent: EP1085019 A1, 2001 ;

233610-77-0+91168-31-95-甲氧基-2-(甲基硫代)苯并咪唑→73590-85-9乌非拉唑

参考文献

Kuraray Co., Ltd.
Patent: US6350876 B2, 2002 ;
Location in patent: Example 23 ;

220757-74-45-甲氧基-2-{[(4-氯-3,5-二甲基-吡啶-2-基)甲基]硫代}-1H-苯并咪唑+124-41-4甲醇钠→73590-85-9乌非拉唑

参考文献

Kuraray Co., Ltd.
Patent: US6350876 B2, 2002 ;
Location in patent: Example 22 ;

86604-80-04-甲氧基-2,3,5-三甲基吡啶-n-氧化物→73590-85-9乌非拉唑

参考文献

Synthetic Communications, , vol. 32, # 8 p. 1211 - 1217

37052-78-12-巯基-5-甲氧基苯并咪唑+84006-10-02-(氯甲基)-4-甲氧基-3,5-二甲基吡啶→73590-85-9乌非拉唑

参考文献

Rane; Pathak; Kaushik; Prasad Rao; Kumar, Ashok
Synthetic Communications, 2002 , vol. 32, # 8 p. 1211 - 1217

73590-85-9乌非拉唑→161973-11-1

参考文献

HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; VAMSI KRISHNA, Bandi
Patent: WO2012/104863 A2, 2012 ;