3-乙酰氨基-4-甲基-2-硝基苯硼酸合成路线 （共 5 条）
反应条件
1: With nitric acid T=-5 - 0°C; 1.75 h; 2: With water T=0°C; 0.5 h; 3: With acetic acid T=65°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2007/76092 A2, 2007 ;
Location in patent: Page/Page column 71 ;
WO 2007/076092 A2
反应条件
nitric acid T=0°C; Nitration;
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
反应条件
1: 98 percent / acetic acid 2: 71 percent / HNO3 / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 56, # 44 p. 8735 - 8746
反应条件
hydrogenchloride; water in 1,4-dioxane T=80°C; 16 h;
参考文献
AMGEN INC.
Patent: WO2007/76092 A2, 2007 ;
Location in patent: Page/Page column 71 ;
WO 2007/076092 A2
反应条件
1: With potassium hydroxide; water 48 h; Heating / reflux; 2: With hydrogenchloride in water pH=1;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2007/125405 A2, 2007 ;
Location in patent: Page/Page column 27; 87 ;
WO 2007/125405 A2
