2-氰基-4-甲基戊酸乙酯合成路线 （共 19 条）
反应条件
(i) Na, toluene, (ii) ClO3F; Multistep reaction;
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
1: (i) EtOH, (ii) ClO3F 2: aq. NH3 / methanol View Scheme
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
(i) EtOH, (ii) ClO3F; Multistep reaction;
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
1: (i) Na, toluene, (ii) ClO3F 2: aq. NaOH View Scheme
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
sodium hydroxide in ethanol
参考文献
Gershon,H. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 536 - 541
反应条件
1.1: caesium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 60 - 65 °C 2.1: water; lithium hydroxide hydrate / 12 h / 70 °C 2.2: 20 °C / pH 2 3.1: sulfuric acid / ethyl acetate / 4 h / Reflux 4.1: ethyl acetate / 20 °C / Reflux 5.1: hydrogenchloride / dichloromethane; water / 1 h 5.2: 2 h / 20 - 25 °C View Scheme
反应条件
1: H2 / Raney-Ni / ethanol 2: aq. HCl View Scheme
参考文献
Testa,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 639, p. 166 - 180
反应条件
1: With piperidine; acetic acid in ethylene glycol dimethyl ether
T=20°C; Knoevenagel Condensation;
2: With hydrogen; palladium 10 on activated carbon in ethylene glycol dimethyl ether
P=2206.72 Torr; Parr autoclave; Product distribution / selectivity;
参考文献
LUPIN LIMITED; ROY, Bhairab, Nath; SINGH, Girij, Pal; LATHI, Piyush, Suresh; AGRAWAL, Manoj, Kunjabihari; MITRA, Rangan; RUPNAWAR, Manoj, Dattatraya
Patent: WO2012/59797 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
反应条件
hydrogen; hydrotalcite-supported palladium nanoparticles; palladium in toluene
T=60°C; P=760 Torr; 1 h;
参考文献
Motokura, Ken; Fujita, Noriaki; Mori, Kohsuke; Mizugaki, Tomoo; Ebitani, Kohki; Jitsukawa, Koichiro; Kaneda, Kiyotomi
Chemistry - A European Journal, 2006 , vol. 12, # 32 p. 8228 - 8239
反应条件
1: cyanoacetic acid ethyl ester With sodium hydride in paraffin oil (nujol); N,N-dimethyl-formamide
T=10 - 50°C; Inert atmosphere;
2: 2-methyl-1-bromopropane in paraffin oil (nujol)
T=20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
LUPIN LIMITED; ROY, Bhairab, Nath; SINGH, Girij, Pal; LATHI, Piyush, Suresh; AGRAWAL, Manoj, Kunjabihari; PISE, Vijay, Sadashiv
Patent: WO2011/141923 A2, 2011 ;
Location in patent: Page/Page column 38-39 ;
