3-(吡啶-2-基)丙烯酸乙酯合成路线 （共 9 条）
反应条件
ethanol; nickel T=160°C; P=88260.9 Torr; Hydrogenation.Erhitzen des Reaktionsprodukts mit wss. HCl;
参考文献
Murakoshi
Yakugaku Zasshi, 1958 , vol. 78, p. 594,596
Chem.Abstr., 1958 , p. 18409
反应条件
hydrogen; palladium on activated charcoal in ethanol P=258.6 Torr; 4 h;
参考文献
Hallinan, E. Ann; Hagen, Timothy J.; Husa, Robert K.; Tsymbalov, Sofya; Rao, Shashidhar N.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3293 - 3299
反应条件
diisobutylaluminium hydride in toluene 15 h; Ambient temperature;
参考文献
Stambasky, Jan; Malkov, Andrei V.; Kocovsky, Pavel
Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 5 p. 705 - 732
反应条件
1.1: potassium hydroxide / water; diethyl ether / 0.17 h / 0 °C 1.2: 0 - 25 °C 2.1: bromine / diethyl ether / 0.17 h / 25 °C 3.1: hydrogenchloride / water / 3 h / |Reflux View Scheme
参考文献
Janin, Yves L.
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1410 - 1414
反应条件
trimethylaluminum in hexane; dichloromethane 72 h; Ambient temperature;
参考文献
Lewis, Frederick D.; Yoon, Beth A.
Journal of Organic Chemistry, 1994 , vol. 59, # 9 p. 2537 - 2545
反应条件
hydrogen; platinum(IV) oxide in methanol
P=4137.29 Torr; 3 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/124746 A1, 2009 ;
Location in patent: Page/Page column 94 ;
反应条件
1: H2 / 5percent Pd/C / ethanol / 45 °C
2: sodium wire / diethyl ether / 18 h / Ambient temperature
3: ethanol / 7 h / Heating
4: 69 percent / NaOH / H2O; ethanol / 60 °C
5: 36 percent / 2.) ethanolic hydrogen chloride / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
1: H2 / 5percent Pd/C / ethanol / 45 °C
2: sodium wire / diethyl ether / 18 h / Ambient temperature
3: ethanol / 7 h / Heating
4: 69 percent / NaOH / H2O; ethanol / 60 °C
5: 45 percent / 2.) 2 N HBr / 5 h / 145 - 150 °C
View Scheme
参考文献
Brown, Thomas H.; Blakemore, Robert C.; Blurton, Peter; Durant, Graham J.; Ganellin, C. Robin; et al.
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 65 - 72
反应条件
lithium hydroxide in 1,4-dioxane
2 h;
参考文献
Kempf, Dale J.; Codacovi, Lynnmarie; Wang, Xiu Chun; Kohlbrenner, William E.; Wideburg, Norman E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 320 - 330
