3-甲酰基-1H-吲哚-7-羧酸合成路线 （共 5 条）
反应条件
sulfuric acid; hydrogen bromide in dichloromethane 1.5 h;
参考文献
De Dios, Alfonso; Prieto, Lourdes; Martin, Jose Alfredo; Rubio, Almudena; Ezquerra, Jesus; Tebbe, Mark; Lopez De Uralde, Beatriz; Martin, Justina; Sanchez, Ana; LeTourneau, Deborah L.; McGee, James E.; Boylan, Carole; Parr Jr., Thomas R.; Smith, Michele C.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4559 - 4570
反应条件
diisobutylaluminium hydride in tetrahydrofuran; hexane
T=-78°C; 1 h;
参考文献
De Dios, Alfonso; Prieto, Lourdes; Martin, Jose Alfredo; Rubio, Almudena; Ezquerra, Jesus; Tebbe, Mark; Lopez De Uralde, Beatriz; Martin, Justina; Sanchez, Ana; LeTourneau, Deborah L.; McGee, James E.; Boylan, Carole; Parr Jr., Thomas R.; Smith, Michele C.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4559 - 4570
反应条件
ethylmagnesium bromide in tetrahydrofuran
1.) 0 deg C, 30 min, r.t., 30 min; 2.) r.t., overnight;
参考文献
Kondo, Yoshinori; Yoshida, Akihiro; Sato, Shuichiroh; Sakamoto, Takao
Heterocycles, 1996 , vol. 42, # 1 p. 105 - 108
反应条件
1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran / 2 h / -78 °C
2.1: DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C
View Scheme
参考文献
De Dios, Alfonso; Prieto, Lourdes; Martin, Jose Alfredo; Rubio, Almudena; Ezquerra, Jesus; Tebbe, Mark; Lopez De Uralde, Beatriz; Martin, Justina; Sanchez, Ana; LeTourneau, Deborah L.; McGee, James E.; Boylan, Carole; Parr Jr., Thomas R.; Smith, Michele C.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4559 - 4570
反应条件
lithium diisopropyl amide
1) THF, hexane, -65 deg C to 0 deg C, 2) -78 deg C to rt, THF, overnight; Yield given. Multistep reaction;
参考文献
Gribble; Keavy; Davis; Saulnier; Pelcman; Barden; Sibi; Olson; BelBruno
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5878 - 5891
