3-(1-哌啶甲基)苯酚合成路线 （共 17 条）
反应条件
formic acid T=110°C; 2 h;
参考文献
Buschauer; Postius; Szelenyi; Schunack
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 7 p. 1025 - 1029
反应条件
ammonia in hydrogenchloride; methanol; ethyl acetate
参考文献
Snow Brand Milk Products Co., Ltd.
Patent: US5317026 A1, 1994 ;
反应条件
hydrogen bromide in water T=125°C; 3 h;
参考文献
Mustazza, Carlo; Borioni, Anna; Giudice, Maria Rosaria Del; Gatta, Franco; Ferretti, Rosella; Meneguz, Annarita; Volpe, Maria Teresa; Lorenzini, Paola
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 2 p. 91 - 109
反应条件
palladium/carbon catalyst in ethanol
参考文献
US4318913 A1, ;
US 4318913 A
反应条件
hepatocytes in methanol T=37°C; Oxidation; dealkylation; glucuronidation; 3 h; Enzymatic reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
Xenobiotica, , vol. 29, # 3 p. 253 - 268
反应条件
1: 92.5 percent / NaOH / dimethylformamide / 2 h / 85 - 90 °C 2: 95.5 percent / K2CO3 / CH2Cl2 / 0.5 h / 0 - 5 °C View Scheme
参考文献
Tarpanov, Velichko; Vlahov, Radoslav; Penkov, Miho; Krikorian, Dikran; Parushev, Stoyan; Mechkarova, Pepa; Angelova, Nely; Schunack, Walter
Synthetic Communications, 1999 , vol. 29, # 1 p. 15 - 20
反应条件
1: 92.5 percent / NaOH / dimethylformamide / 2 h / 85 - 90 °C 2: 95.5 percent / K2CO3 / CH2Cl2 / 0.5 h / 0 - 5 °C 3: 70.3 percent / dimethylformamide / 1 h / 90 °C View Scheme
参考文献
Tarpanov, Velichko; Vlahov, Radoslav; Penkov, Miho; Krikorian, Dikran; Parushev, Stoyan; Mechkarova, Pepa; Angelova, Nely; Schunack, Walter
Synthetic Communications, 1999 , vol. 29, # 1 p. 15 - 20
反应条件
sodium chloride in sodium hydroxide; dimethyl sulfoxide; benzene
参考文献
Snow Brand Milk Products Co., Ltd.
Patent: US5317026 A1, 1994 ;
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=85 - 90°C; 2 h;
参考文献
Tarpanov, Velichko; Vlahov, Radoslav; Penkov, Miho; Krikorian, Dikran; Parushev, Stoyan; Mechkarova, Pepa; Angelova, Nely; Schunack, Walter
Synthetic Communications, 1999 , vol. 29, # 1 p. 15 - 20
反应条件
1: 79 percent / 1.) 40 percent benzyltrimethylammonium hydroxide/MeOH, 2.) gaseous HCl / diethyl ether; propan-2-ol / 24 h / Heating 2: 60 percent / LiAlH4 / diethyl ether / 0.5 h / Ambient temperature View Scheme
参考文献
Buschauer; Postius; Szelenyi; Schunack
Arzneimittel-Forschung/Drug Research, 1985 , vol. 35, # 7 p. 1025 - 1029
