3-溴-2,6-二甲氧基苯甲酸合成路线 （共 9 条）
反应条件
bromine in acetic acid 1.5 h;
参考文献
Cuyegkeng, Maria Assunta; Mannschreck, Albrecht
Chemische Berichte, 1987 , vol. 120, p. 803 - 810
参考文献
Journal of the Chemical Society, , p. 497 - 506
反应条件
1: SOCl2 / 0.5 h / Heating 2: 10N aq. NaOH / CHCl3 / 0.17 h / Heating View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
参考文献
Thurkauf, Andrew; Yuan, Jun; Chen, Xi; Wasley, Jan W. F.; Paneitz, Gregory; Meade, Robin; Woodruff, Kristine Harris; Huston, Kevin; Ross, Philip C.
Medicinal Chemistry Research, 1996 , vol. 6, # 2 p. 69 - 80
反应条件
sulfuryl dichloride in chloroform
1.) RT, 12 h, 2.) reflux, 45 min;
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: 80 percent / SO2Cl2 / CHCl3 / 1.) RT, 12 h, 2.) reflux, 45 min
2: SOCl2 / 1 h / Heating
3: butan-2-one / 0.5 h
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
thionyl chloride
0.5 h; Heating;
参考文献
de Paulis; Kumar; Johansson; Raemsby; Florvall; Hall; Angeby-Moeller; Ogren
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1263 - 1269
反应条件
1: 80 percent / SO2Cl2 / CHCl3 / 1.) RT, 12 h, 2.) reflux, 45 min
2: SOCl2 / 1 h / Heating
View Scheme
参考文献
Florvall, Lennart; Oegren, Sven-Ove
Journal of Medicinal Chemistry, 1982 , vol. 25, # 11 p. 1280 - 1286
反应条件
1: SOCl2
2: 28 percent / NaH / dimethylformamide / 5 h / Ambient temperature
View Scheme
参考文献
Ferranti; Garuti; Giovanninetti; Borgatti; Bartoletti
Archiv der Pharmazie, 1985 , vol. 318, # 1 p. 78 - 84
