乙基5-氧代-5-苯基戊酸酯合成路线 （共 27 条）
反应条件
lithium aluminium tetrahydride in diethyl ether Heating;
参考文献
Cousseau,J.; Lamant,M.
Bulletin de la Societe Chimique de France, 1967 , p. 4702 - 4707
反应条件
1: 38 percent / 2-chloro-3-ethylbenzoxazolium tetrafluoroborate; Et3N / CH2Cl2 / 16 h / 20 °C 2: aq. NaOH / dioxane / 3 h / 20 °C View Scheme
参考文献
Rosenblum, Stuart B.; Huynh, Tram; Afonso, Adriano; Davis Jr., Harry R.
Tetrahedron, 2000 , vol. 56, # 31 p. 5735 - 5742
反应条件
1: pTsOH / benzene / Heating 2: LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Shindo, Mitsuru; Matsumoto, Kenji; Sato, Yusuke; Shishido, Kozo
Organic Letters, 2001 , vol. 3, # 13 p. 2029 - 2030
反应条件
hydrogen; nickel in ethanol
T=40 - 50°C; P=38000 Torr;
参考文献
Cousseau,J.; Lamant,M.
Bulletin de la Societe Chimique de France, 1967 , p. 4702 - 4707
反应条件
1: ethyl α,α-dibromocaproate With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78 - 0°C; 3.5 h;
2: ethyl 5-oxo-5-phenylpentanoate in tetrahydrofuran; pentane
T=-78°C; 5 h;
3: With silica gel in benzene
10 h; Heating; Further stages.;
参考文献
Shindo; Sato; Shishido
Journal of Organic Chemistry, 2001 , vol. 66, # 23 p. 7818 - 7824
反应条件
1: pentane; tetrahydrofuran / -78 °C
2: SiO2 / benzene / Heating
View Scheme
参考文献
Shindo, Mitsuru; Sato, Yusuke; Shishido, Kozo
Journal of the American Chemical Society, 1999 , vol. 121, # 27 p. 6507 - 6508
反应条件
silica gel
1.) pentane, THF, -78 deg C, 2.) benzene, reflux; Yield givenMultistep reaction;
参考文献
Shindo, Mitsuru; Sato, Yusuke; Shishido, Kozo
Journal of the American Chemical Society, 1999 , vol. 121, # 27 p. 6507 - 6508
