N-(3-氰基吡啶-2-基)-n-甲基甲烷磺酰胺合成路线 （共 3 条）
反应条件
1,3,4,6,7,8-hexahydro-1-methyl-2H-pyrimido{1,2-a}pyrimidine; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in dichlorobenzene, 1,2-
T=100°C; Buchwald-Hartwig amination; 1 h;
参考文献
THE SCRIPPS RESEARCH INSTITUTE
Patent: WO2008/115369 A2, 2008 ;
Location in patent: Page/Page column 98-99 ;
WO 2008/115369 A2
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
2 h; Reflux;
参考文献
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VAN CAMP, Jennifer; XU, Xiangdong; OSUMA, Augustine, Toby; GREGG, Robert; LONGENECKER, Kenton, L.
Patent: WO2012/45195 A1, 2012 ;
Location in patent: Page/Page column 82-83 ;
WO 2012/045195 A1
反应条件
ammonia; hydrogen; palladium 10 on activated carbon in methanol; water
P=2585.81 Torr;
参考文献
CEPHALON, INC.; CURRY, Matthew A.; DORSEY, Bruce D.; DUGAN, Benjamin J.; GINGRICH, Diane E.; MESAROS, Eugen F.; MILKIEWICZ, Karen L.
Patent: WO2010/141796 A2, 2010 ;
Location in patent: Page/Page column 215 ;
