hydrogenchloride; thionyl chloride in 1,4-dioxane; methanol T=25°C; 18 h;

hydrogenchloride; thionyl chloride in 1,4-dioxane; methanol T=-10 - 21°C; Esterification; 18 h; SOCl2 adding to a pre-cooled susp. of the acid in MeOH, stirring under Ar, evapg., treated with aq. K2CO3 and with 4 N HCl;

thionyl chloride 18 h; Ambient temperature;

1: SOCl2 / 18 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme