5-溴苯并[B]噻吩-3-甲酸合成路线 （共 6 条）
反应条件
sodium hydroxide; bromine in 1,4-dioxane T=0 - 20°C;
参考文献
Mitsumori, Susumu; Tsuri, Tatsuo; Honma, Tsunetoshi; Hiramatsu, Yoshiharu; Okada, Toshihiko; Hashizume, Hiroshi; Inagaki, Masanao; Arimura, Akinori; Yasui, Kiyoshi; Asanuma, Fujio; Kishino, Junji; Ohtani, Mitsuaki
Journal of Medicinal Chemistry, 2003 , vol. 46, # 12 p. 2446 - 2455
反应条件
1: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C 2: 77 percent / aq. NaOH; Br2 / dioxane / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 12 p. 2446 - 2455
反应条件
1: 42.35 g / PPA / chlorobenzene / 15 h / Heating 2: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C 3: 77 percent / aq. NaOH; Br2 / dioxane / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 12 p. 2446 - 2455
反应条件
1: NaOMe / methanol / 3.5 h / Heating 2: 42.35 g / PPA / chlorobenzene / 15 h / Heating 3: 90 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / 0 - 20 °C 4: 77 percent / aq. NaOH; Br2 / dioxane / 0 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 12 p. 2446 - 2455
反应条件
N-bromosuccinmide; trifluoroacetic acid in chloroform T=20°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 52, # 29 p. 3736 - 3739
反应条件
1: With triethylamine; isobutyl chloroformate in tetrahydrofuran T=0°C; 2 h; 2: With sodium tetrahydroborate; water in tetrahydrofuran T=0 - 20°C; 14.5 h;
参考文献
WO2008/109333 A1, ;
Page/Page column 79-80 ;
WO 2008/109333 A1
