1,2-苯异噁唑-3-甲烷磺酰氯合成路线 （共 7 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene T=25 - 50°C; 6 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/16209 A2, 2007 ;
Location in patent: Page/Page column 13 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene T=25 - 50°C; 5.5 h;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2007/16208 A2, 2007 ;
Location in patent: Page/Page column 15-16 ;
反应条件
T=70 - 80°C; 6 - 8 h;
参考文献
WO2005/44808 A1, ;
Page/Page column 10 ;
反应条件
ammonia in toluene T=2 - 15°C; pH=9;
参考文献
WO2007/16208 A2, ;
Page/Page column 16-17 ;
反应条件
ammonia in toluene T=10 - 15°C;
参考文献
US2004/14983 A1, ;
Page 4-5 ;
反应条件
in ethyl acetate
Ambient temperature;
参考文献
Uno,H. et al.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 180 - 183
反应条件
1: NH3 / ethyl acetate
2: Heating
View Scheme
参考文献
Uno,H. et al.
Journal of Medicinal Chemistry, 1979 , vol. 22, p. 180 - 183
