acetic acid 10 h; Heating;

sodium hydroxide 0.0833333 h; Heating;

1: 88 percent / sodium / methanol; tetrahydrofuran / 1 h 2: 40 percent / M sodium hydroxide / 0.08 h / Heating View Scheme

1: 1.) 1-butyllithium / 1.) tetrahydrofuran/hexane, -78 deg C, 10 min, -20 deg C, 2 h; 2.) tetrahydrofuran/hexane, -78 deg C, 1 h 2: 90 percent / 80percent aq. acetic acid / 10 h / Heating View Scheme